It was Aho's fifth NHL hat trick and first since May 3, 2021, against the Chicago Blackhawks.
"I'm not going to lie, it felt good to get the hat trick," Aho said. "[Martin Necas, Andrei Svechnikov and Jesperi Kotkaniemi] have been bailing our line more this season than us to them. It's kind of nice to return the favor there."
Necas had a goal and two assists, and Svechnikov, Seth Jarvis and Teuvo Teravainen each had two assists for the Hurricanes (8-2-1), who have won four in a row, including a 4-3 shootout victory against the Tampa Bay Lightning on Thursday. Antti Raanta made 22 saves.
"We're a confident group, that's for sure," Carolina coach Rod Brind'Amour said. "What I see is just consistency with [Aho's] play. Every night is pretty much the same. Elite players, that's how they go. Every night, if they're not your top guy, you notice them and they're impactful."
Victor Olofsson scored his ninth goal of the season, Jack Quinn had two assists, and Craig Anderson made 28 saves for the Sabres (7-4-0), who had won three straight.
"We weren't as sharp tonight, and I would say there were a handful of guys that didn't look like themself," Buffalo coach Don Granato said. "It happens. They tried to fight through. I don't question their compete, I don't question their effort."
Jacob Bryson gave the Sabres a 1-0 lead 28 seconds into the first period when the rebound from his shot went in off Svechnikov.