Florida needed the Philadelphia Flyers to lose in regulation Saturday, and to win their final two games; the Flyers defeated the New York Rangers 5-0.
The Panthers, who have won the first three games of their four-game homestand, will be without center Aleksander Barkov, who sustained an upper-body injury in a 3-2 victory against the Bruins on Thursday.
The Sabres have lost three in a row, including a 7-5 decision against the Tampa Bay Lightning on Friday.