It was Reinhart's first game against the Sabres since the forward was traded to the Panthers on July 24. He scored 295 points (134 goals, 161 assists) in 454 games with Buffalo.
"I thought he was great," Panthers coach Andrew Brunette said. "I think when Sammy moves his feet and works and gets on pucks, uses his body, I think the rest of his skill level … his IQ is off the charts, and it enables him to make those plays. It was really fun watching that line play. They were a joy to watch tonight."
Jonathan Huberdeau had a goal and four assists, and Aaron Ekblad scored twice and had an assist for the Panthers (16-4-3), who have won 13 of 14 at home. Spencer Knight made 19 saves in relief after Sergei Bobrovsky allowed four goals on 12 shots.
"Just try to change it up, try to change momentum a little bit there," Brunette said. "It wasn't anything with 'Bob.' Our breakdowns were horrific in the first period, and we didn't give him any help there."
Vinnie Hinostroza scored twice for the Sabres (8-12-3), who are 1-5-1 in their past seven games. Aaron Dell made 38 saves.
"They're a good team," Buffalo center Casey Mittelstadt said. "That's how they want to play, that's what they want to do to you. They've been doing it to a lot of teams this year.
"But yeah, I just think at some point when they're coming after us, we've got to fight back, and I think that's about it. Stop the bleeding. It's been kind of a sour spot for a lot of years, so that's on us as players. We've got to go out and win the next shift and, yeah, we just let the momentum get too far in their favor."