The Penguins had two goals overturned on coach's challenges from the Sabres.
Drew O'Connor appeared to score in front at 15:50 off a backhand pass from Sidney Crosby, but the goal was disallowed after video review determined that Crosby was offside.
Jake Guentzel then deflected a shot from Crosby past Luukkonen at 18:55, but the goal was overturned after video review showed Guentzel interfered with the Buffalo goalie.
"It's incredible. I think that was the most confident, poised I've seen him play in his whole career," Tuch said of Luukkonen. "He's got a shutout or two, but that was just so much confidence. You know what? A couple of goals against that ended up going back and he didn't get rattled at all.
"He went right back in there, made a couple big saves on breakaways. Never wavered. I thought he was reading the play really well."
Pittsburgh then failed to score on three breakaways. Crosby had a snap shot turned away at 5:29 of the first before before Rakell had a wrist shot denied at 5:32 of the second period. Guentzel couldn’t put a backhand through Luukkonen’s five-hole at 15:55.
"They were good reads," Luukkonen said. "It feels good to make those saves in those types of games and those types of situations. Sometimes that happens, there's some defensive breakdowns, but it feels good to come up with the saves."