Letang, who missed Pittsburgh's past eight games because of a lower-body injury, participated in full contact in practice Sunday, when he returned to the top defense pair with Brian Dumoulin.
The Penguins are 2-0-2 in their past four games, and 4-1-3 in their past eight.
Brodie, who has missed the past five games, practiced with Calgary on Sunday for the first time since experiencing a medical episode in practice Nov. 14. The defenseman collapsed during a drill, started convulsing and was taken off the ice on a stretcher before being transported to a hospital.
The Flames have been outscored 25-7, including being shut out three times, while going 1-5-1 in their past seven games after winning four of their previous five. They defeated the Philadelphia Flyers 3-2 in a shootout Saturday.