Filip Zadina cut it to 2-1 at 11:35 of the second period, scoring as the trailer after Moritz Seider banked the puck off Francouz's pads on a 2-on-1. Larkin had the secondary assist on the play, his 200th in the NHL.
"I didn't think 2-0 was insurmountable because we know we will get chances to score against that team," Red Wings coach Jeff Blashill said. "They are just so good in the O-zone and on the rush, even without Nathan MacKinnon. It's amazing how well they are playing without him."
Nazem Kadri made it 3-1 at 18:19, knocking home a loose puck in the crease, and Valeri Nichushkin extended the lead to 4-1 at 2:11 of the third period.
"I thought the third goal killed us, and so did the fourth one," Blashill said. "We had it within 2-1, and I thought we were taking the play to them, but the third goal changes everything.
"Then we take a penalty at the end of the period and give them more momentum."
Robby Fabbri's power-play goal pulled Detroit to within 4-2 at 9:38, but Landeskog shot into an empty net at 19:21 for the 5-2 final.
NOTES: Larkin, who had two assists, has scored 16 points (six goals, 10 assists) in an eight-game point streak. Seider also had two assists and has scored eight points (one goal, seven assists) in a five-game point streak. … The Avalanche are 9-1-1 in their past 11 road games.