MacKinnon scored his 30th goal to give Colorado a 2-1 lead at 7:24 of the second. He took Denis Malgin's pass at center ice, broke through the defense and put the puck past Husso to become the fifth Avalanche/Quebec Nordiques player with at least five 30-goal seasons, joining Joe Sakic (nine), Peter Stastny (eight), Michel Goulet (eight) and Milan Hejduk (five).
Bowen Byram scored on a 4-on-3 power play to make it 3-1 at 17:37. Lars Eller's short-handed goal at 4:20 of the third put Colorado ahead 4-1, and Rantanen made it 5-1 at 5:16.
"At 3-1, we had a power play in what was still a very winnable game," Red Wings captain Dylan Larkin said. "But we gave up a shorty and then gave up another goal. We're not good enough to have lapses like that."
Red Wings defenseman Simon Edvinsson, the No. 6 pick in the 2021 NHL Draft, had one shot on goal and was minus-1 in 15:34 of his NHL debut.
"You have to be ready to play every team in the NHL, but this was certainly an interesting way to start," he said. "I felt comfortable out there, but there are still some things I need to clean up."
NOTES:Makar had the 19th three-point game of his NHL career, two more than Tyson Barrie for the Avalanche/Nordiques record among defensemen. Makar has 241 points (64 goals, 177 assists) in 233 NHL games; his average of 1.03 points per game is third among defensemen (minimum 200 games) in League history, trailing Bobby Orr (1.39) and Paul Coffey (1.09) … Detroit has allowed an NHL-high 12 short-handed goals. ... The Avalanche extended their winning streak against the Red Wings to 10 games, tying the longest run against one opponent in Avalanche/Quebec Nordiques history (Buffalo Sabres, March 7, 2007 to Jan. 20, 2016; Columbus Blue Jackets, Oct. 14, 2000 to Jan. 23, 2003; Pittsburgh Penguins, Oct. 21, 1982 to Oct. 19, 1985).