Hartman gave Minnesota a 1-0 lead at 8:40 of the first period, scoring off a one-handed pass from Bjugstad in the slot.
"We should have played the same in the second period," Wild coach Dean Evason said. "And I say the first was good. We still weren't in their face enough, frustrating them and putting pressure on them as much as we would like to, or would have liked to, in the first period. We played good, but you can't get down against any team obviously two, three goals. It's very difficult to come back."
MacKinnon scored on a breakaway 18 seconds into the second period to tie it 1-1 before Burakovsky scored on a rebound at 1:29 to make it 2-1.
Brandon Saad extended the lead to 3-1 at 15:48 after corralling a loose puck near the right post, and J.T. Compher deflected a point shot from Cale Makar to make it 4-1 at 17:52.
"You have to have the balanced scoring," Bednar said. "We know what our top guys are capable of, and they'll run into games when they get shutdown or things don't go their way or a goalie makes some saves.
"Depth is huge, and to have those guys spread out like that and scoring goals is a really important reason why we're on the run we're on."
Colorado outshot Minnesota 20-5 in the second period.
"We didn't play them hard in the second period," Hartman said. "We made it easy on them and we kind of kicked ourselves after the second, talked about how to play them, and guys pushed back and we made it a lot harder for them in the third period."