Darcy Kuemper made nine saves on 10 shots before leaving at 19:03 of the first period after Predators forward Ryan Johansen's stick hit him in the eye through his mask. He was replaced by Pavel Francouz, who made 18 saves on 20 shots.
"I didn't see what happened initially to Darcy, but I only saw that he was having a lot of pain and I was sure that I'm going in right away," Francouz said. "It's always tough when you see a goalie get hurt, but you have to focus all of your thoughts on the game, on the puck, so that was something I was trying to do. I had huge support from my teammates."
RELATED: [Complete Avalanche vs. Predators series coverage]
Colorado coach Jared Bednar said Kuemper's injury was not too serious and did not rule him out for Game 4.
"He's doing better, and we'll get him further evaluated," Bednar said. "He's got some swelling there, obviously was unable to return, but hopefully he's doing good and is able to get back in the net."
Matt Duchene scored his third goal of the series, Alexandre Carrier had two assists, and Connor Ingram made 34 saves for Nashville, the second wild card in the Western Conference.
The Predators are trailing 3-0 in a Stanley Cup Playoff series for the first time in their history.
"We liked our game, [and I] thought we played a lot better than we did in the first two games," Predators captain Roman Josi said. "[We've] got to stay aggressive. There's not one person in this room that doesn't believe that we can turn this around. We're going to come out Monday and play aggressive. ... We believe we can beat this team."