Robert Thomas scored, and Jordan Binnington made 21 saves for the Blues (18-16-1), who had their three-game winning streak end.
"I'll take that effort every night," St. Louis coach Drew Bannister said. "I thought we competed and played well. Maybe 10 minutes of the second period that we got away from our game, but I thought we certainly deserved a better result. Our guys competed, they played well. There are some times that you're the better team and bounces don't go your way, it just happens. For us, it's just about regrouping ourselves for tomorrow (at the Pittsburgh Penguins) and getting ready."
Manson had a goal overturned at 6:01 of the first period when the Blues successfully challenged for goaltender interference by Avalanche forward Kurtis MacDermid.
"I just wasn't sure if it was our own [defenseman] or their player," Binnington said. "Fortunately, it was their guy."
Johansen gave Colorado a 1-0 lead at 15:11 on a rebound from the slot.
“I thought he played great tonight," Bednar said. "He worked hard, he checked hard, he obviously goes to the net on both of those goals. He had a good night. We needed it. We needed a little bit of offense from somebody else in this game, and we got it."
Thomas tied it 1-1 at 16:31, deking to his backhand on a short-handed breakaway after intercepting a pass by MacKinnon at the St. Louis blue line. The short-handed goal was the ninth for the Blues this season, tied with the Philadelphia Flyers for the most in the NHL.
"Nothing changed for us, really," St. Louis defenseman Colton Parayko said. "I think obviously our forwards did a good job of coming back and helping in support. I know they had their sticks in there quite a bit and interrupted a bit. Everyone just stayed tight on them (the top players for Colorado) in the [defensive] zone and things like that. But credit to the forwards for kind of staying tight."
Binnington stopped Cale Makar on a penalty shot at 7:56 of the third after it was ruled that Blues forward Mackenzie MacEachern threw his broken stick at the puck near the blue line.
NOTES: Colorado's franchise point-streak record is held by Mats Sundin(30 games with the Quebec Nordiques in 1992-93). … Avalanche forward Ross Colton was scratched with a lower-body injury and replaced by Ben Meyers, who played 8:11 after being recalled from Colorado Springs of the American Hockey League on Thursday. … Binnington tied Grant Fuhr for the fourth-most games played by a goalie in Blues history (249). … Thomas played an NHL career-high 24:09 and has 11 points (four goals, seven assists) in his past seven games. … Faulk sustained a lower-body injury in the final minute of the third period and will not travel to Pittsburgh while he is evaluated.