Jenner cut the lead to 2-1 at 4:21 of the second period when he got to a loose puck in the slot and shot blocker side. Marchenko, who has 14 goals, had the assist on the play, his first in the NHL (30th game)
Marchenko then tied it 2-2 at 15:01, converting on a rebound at the top of the crease after Jenner cut to the net and put a backhand on net.
Sean Kuraly gave the Blue Jackets a 3-2 lead at 15:58. Mathieu Olivier and Johnson dug the puck off Woll's pad to Kuraly, who buried a shot into an open net.
"Truthfully, I thought we were really good in the first, and then it's just like a small lapse that ends up costing you," Maple Leafs defenseman Morgan Rielly said. "There's plenty of good players in this League, guy on teams all over, up and down standings. If you don't play well, and you don't play your structure and play hard and compete, they're going to make you pay.
"We just didn't play well enough. We didn't compete. They outworked, outchanced us, and take over the game. You put yourself in a difficult situation."
After trailing 2-0 and being outshot 11-4 after the first period, Columbus outshot Toronto 21-10 in the second.
"There's so many times where you come in with a good second and then the third, they take over again. It happens all the time," Larsen said. "I don't love that we got scored on [in the third], I loved how we responded after we got scored on. We came back and we just stuck to the game plan, and that's a great sign."
Rielly tied it 3-3 at 1:20 of the third period on a power play when he one-timed a pass from Marner at the bottom of the right face-off circle.
"That's a spot we want to get better at, going into the third with a lead, learning how to defend," Jenner said. "That was a gutsy win. They got one early, and then we found one in the third. A lot of blocks, a lot of great efforts defensively, and listen, we got the job done, so it feels good when you win that one."