Henry Thrun and Luke Kunin scored for the Sharks, who lost for the 21st time in 24 games. Mackenzie Blackwood made 22 saves in defeat.
Crouse opened the scoring with a power-play goal 3:17 into the first period, one-timing a shot from the top of the left circle past Blackwood. The 26-year-old now has two goals and an assist in his last four games.
Thrun tied it up just over a minute later with a power-play goal of his own, beating Ingram with a slapshot from just inside the blue line.
O’Brien restored the Coyotes’ one-goal lead at 11:07 of the first, firing a shot at Blackwood that found its way through and had just enough steam to cross the line, making it 2-1 heading into the first intermission.
Kunin tied it at 11:40 of the second period, beating Ingram from in-close to make it 2-2, but Guenther put Arizona up again with a wrister from the slot. The 20-year-old is tied for the team lead with four game-winning goals, alongside Keller and Michael Carcone.
"I feel pretty good," Guenther said. "I think I'm playing pretty well. My linemates are doing a pretty good job, and I'm just finding those areas."
Keller gave Arizona a two-goal cushion at 14:13 of the final frame, finshing off a between-the-legs pass from Nick Schmaltz with a one-timer from the top of the left circle to make it 4-2. The four-time All-Star extended his NHL-leading point streak to 11 games, which is the second-longest streak of his career.
Schmaltz added an empty-netter at 16:54 to ice the game.
"We're pretty level-headed and we're doing a good job," Guenther said. "There's always something to play for, and I truly believe that. These games are important."
The Coyotes are back in action against Seattle on Tuesday in the second game of their five-game road trip. Puck drop is scheduled for 7 pm MST and the game will be broadcast on Arizona 61 (TV) and KTAR News 92.3 FM (Radio).
