The Red Wings thought they had cut the lead to 2-1 at 12:45 of the first period, but the goal was disallowed after it was determined that the referee blew the whistle to stop play before Perron's shot crossed the goal line.
Sanderson made it 3-0 at 13:09 of the second when he one-timed a pass from Vladimir Tarasenko at the left hash marks with the teams skating 4-on-4.
"We thought we gave them too much in the first period," Detroit captain Dylan Larkin said. "We took a retaliatory penalty and then we missed two assignments on the 4-on-4 and the Tkachuk second goal. That was a tough start, a tough three plays after we had a good start."
Norris made it 4-0 at 1:18 of the second when he took a pass from Mathieu Joseph on a give-and-go and shot from the right dot.
"I thought we come out, looked maybe a little nervous in the first period," Senators coach D.J. Smith said. "I thought we scored easy, we put it in the net but I don't think it was indicative maybe of the play, and that kind of lulled us to sleep. We didn't forecheck in the second period, we looked like we just wanted to hang on to it and kill the clock and clearly we got burned, but I'm proud of the guys, between periods, to regroup, come back out and stick with it."
NOTES: Ottawa was 1-for-6 on the power play; Detroit was 0-for-3. ... The Red Wings will play the Toronto Maple Leafs on Friday, the Senators play the Minnesota Wild on Saturday and the Maple Leafs face the Wild on Sunday as part of the Global Series. … Stutzle has nine points (two goals, seven assists) in his past four games. … Larkin played his 600th NHL game; he had three shots on goal and was minus-2 in 20:27 of ice time. … Detroit became the first team to score four or more goals in a single period in a regular-season game played outside North America. … It was the first time this season the Senators played a game that went past regulation; the Red Wings are 1-3 this season after regulation.