Bertuzzi gave the Red Wings a 1-0 lead at 11:48 of the first period when he drove to the net and tucked a shot past Talbot's outstretched right pad.
Jake Sanderson tied it 1-1 at 3:41 of the second period with a slap shot from the point through traffic on a power play.
"It was one of our better performances, physically, in a while," Ottawa coach D.J. Smith said. "We played a playoff-style game. Early on they had a good push. They started with the lead, but we stayed with it and put pucks in and used everyone, really. But ultimately, I've said it plenty, when your best players are your best players, you usually win."
Detroit was without one of its top penalty killers, forward Michael Rasmussen, who is out indefinitely with a knee injury.
"I think we missed him big time tonight in a game like this," Red Wings captain Dylan Larkin. "Someone's going to have to step up and play. You know, he's kind of created a role, he does things that no one else on our team really does, and we miss that. But someone's going to have to step in and step up for us. I expect that tomorrow."
Perron put Detroit back in front 2-1 at 5:11 with his own power-play goal, a wrist shot short side from the left circle.