New Jersey had the top pick after winning the NHL Draft Lottery on April 9. Many expect Hughes to be a top-six forward for the Devils next season, with a good chance he could begin the season as their No. 2 center behind Nico Hischier, the No. 1 pick in the 2017 NHL Draft.
"He's a dynamic player with great hockey sense, good competitiveness and he's a player that makes other players around him better," Devils coach John Hynes said of Hughes.
Devils general manager Ray Shero said he made up his mind to draft Hughes midway through this week.
"What really excites me about Jack is his hockey IQ, his skating, his agility ... just his total instincts as a hockey player with incredibly quick hands," Shero said. "He's a focused kid and he knows what he needs to do, and I think at the IIHF World Championship it was really fantastic for him to play against those NHL players and practice with them, and this is something where we picked Jack Hughes for the short and long term and we're going to help him every step of the way looking for other good players."
Hughes was the first of eight players from the NTDP U-18 team to be selected in the first round; the former record of three was done seven times.
There were 11 United States-born and 11 Canada-born players selected, followed by four Sweden-born, three Finland-born and one player each from Germany and Russia.
NTDP goalie Spencer Knight, who was picked No. 13 by the Florida Panthers, became the first goalie chosen in the top 20 since Andrei Vasilevskiy was No. 19 by the Tampa Bay Lightning in the 2012 NHL Draft.
The only trade of the first round occurred when the Philadelphia Flyers dealt the No. 11 pick to the Arizona Coyotes for the No. 14 pick and the No. 45 pick. The Coyotes used No. 11 to select defenseman Victor Soderstrom of Brynas in the Swedish Hockey League. The Flyers chose NTDP defenseman Cameron York at No. 14.
The biggest surprise of the first round occurred at No. 6, when the Detroit Red Wings selected defenseman Moritz Seider of Mannheim in Germany. Seider was projected by many as a late first-round pick.
"I would say somewhere between 15 and 20," Seider said when asked where he expected to go in the draft. "It's insane. I can't explain it."
The pick was the first under Red Wings general manager Steve Yzerman, who replaced Ken Holland on April 19. Yzerman was the GM of the Tampa Bay Lightning from 2010 to 2018.
"We think he has excellent hockey sense, obviously a big kid, 6-foot-3, real good skater," Yzerman said. "In our opinion he was one of the top defensemen in the draft."
Hughes will travel to New Jersey on Sunday and spend a few days there before returning home to Plymouth, Michigan. The Devils open development camp July 8.
He is the second United States-born player selected with the No. 1 pick in the past four NHL Drafts (2016, Auston Matthews by the Toronto Maple Leafs) and eighth in NHL history.