McDavid scored his first goal of the series in Game 4 and four points (one goal, three assists) in the series. He won the Art Ross Trophy as the leading scorer in the NHL this season with 105 points (33 goals, 72 assists) in 56 games.
"The regular season doesn't mean much now," he said. "The regular season doesn't mean anything."
Oilers defenseman Darnell Nurse played 62:07 in Game 4, the third most in NHL postseason history since time on ice records began at the start of the 1997-98 season. Seth Jones of the Columbus Blue Jackets played 65:06 against the Tampa Bay Lightning in Game 1 of the Eastern Conference First Round on Aug. 11, 2020, and Sergei Zubov of the Dallas Stars played 63:51 against the Mighty Ducks of Anaheim in Game 1 of the Western Conference Semifinals on April 24, 2003.
Nurse, who led Edmonton by averaging 25:38 of ice time per game during the regular season, played 15:32 of the 20 minutes in the first overtime in Game 4 and said his game-high total was no burden.
"[You] just play," he said. "Don't think too much. Situations like that, you've just to go play, go out there and that's the way it worked out, I guess. You just play and adapt. I wish that those minutes went toward a win, that we were still playing.
"We played hard. It [hurts] that we're sitting here after four games and it's a sweep when we took three to overtime. There's things we could have done better here in the end."
The Oilers (35-19-2) were the No. 2 seed in the Scotia North Division, had the top two scorers in the NHL with McDavid and Leon Draisaitl (84 points; 31 goals, 53 assists), and won seven of nine regular-season games against the Jets.
McDavid said small things made a difference in the series and the Oilers don't need a major overhaul for the future.
"I think it's the little mistakes," McDavid said. "It's just the little ones. It's not like it's earth-shattering stuff here. We don't need to leave here and think we've got to [right] the ship here. It's little things. It's a fine line. We talked about those lessons we've learned throughout the years and it's obviously another lesson that we have to take with us moving forward."
Coach Dave Tippett said, "You've got to continue to work and get better. There are some things we can do to help us get better. Some of these lessons are hard to learn, but next time you recognize situations better. There are just things that happen in a game that the only way you can figure them out is to go through them. That's unfortunately some of the challenges we're going through right now."