Kane has two points (one goal, one assist) in his past 11 games and no points in six. Eichel has 25 points (12 goals, 13 assists) in the past 18 games and Okposo has 10 points (three goals, seven assists) in the past eight.
The Sabres have won three of their past four games but are 0-3-0 in their past three at KeyBank Center. Center Jacob Josefson will return to the lineup after missing the past seven games with a lower-body injury. Chad Johnson will start in goal.
Goalie Harri Sateri, a 28-year-old rookie, will make his fourth straight start for the Panthers. Sateri is coming off his first NHL win on Tuesday, when he made 32 saves in a 4-1 victory against the New York Islanders. The Panthers have lost three of their past four games.