Acciari made it 3-1 at 11:17 of the second after he got around Nashville defenseman Mattias Ekholm in the neutral zone and scored glove side on a 2-on-1. He then extended the lead to 4-1 at 18:46 on a rebound of Keith Yandle's shot from the neutral zone.
"I was just focused on trying to play a simple game, not grip the stick too tight and get that first one," Acciari said. "It comes in bunches sometimes and I happened to get three tonight. Hopefully I can continue with that game and try to help out the team, whether it's getting on the board or just blocking a shot."
Arvidsson scored 19 seconds into the third period to cut it to 4-2 on the rebound of a shot by Filip Forsberg.
"There's lots of guys who have good moments in the game but not consistent moments in the game," Nashville coach John Hynes said. "Or there's a good game and then there's a bad one or two bad ones. It's not good enough, and that's on us as a group. We've got to find a way to be more consistent."
Vatrano pushed the lead to 5-2 at 14:56 of the third, and Acciari completed his third NHL hat trick with a power-play goal to make it 6-2 at 16:58.
NOTES: Predators forward Matt Duchene will be out 3-5 weeks because of a lower-body injury. … Yandle played his 999th NHL game. … Panthers defenseman Anton Stralman missed the game because of a lower-body injury and is day to day. … Florida forward Grigori Denisenko, who was selected with the No. 15 pick in the 2018 NHL Draft, had two shots, one hit and one block in 12:59 of ice time in his NHL debut. … Arvidsson's goal was his first since Jan. 30 (16 games). … Forsberg's assist on Tolvanen's goal was his 200th in the NHL in his 482nd game.