Carter Verhaeghe had a goal and an assist, Matthew Tkachuk had two assists, and Spencer Knight made 22 saves in his first game since Jan. 8 for the Panthers (27-24-6), who had won four of five following a 2-1 shootout victory at the Minnesota Wild on Monday.
"We were getting our looks," Verhaeghe said. "I think we were just giving them a ton of looks off the rush and weren't at our best tonight. It's a little frustrating, but [Binnington] played well too.
"We want to win every game, but we know it's not possible. We just want to keep building our game and trying to get better every night, and I think we're on the right track, but tonight wasn't our best."
Schenn gave the Blues a 1-0 lead at 11:27 of the first period on the power play after a wrist shot from defenseman Torey Krug from the point tipped Schenn in front, caromed off the back boards and off the back of Knight's left skate into the net.
"I got a tip on it," Schenn said. "Through 82 games, you need some goals like that every once in a while. Not pretty by any means, but I'll take it."
Schenn made it 2-0 with his second goal 35 seconds into the second period. He scored on a 3-on-1 rush that he kept and shot low glove on Knight after Kyrou intercepted a puck in the defensive zone to spring the odd-man rush.