Steven Stamkos scored his 496th NHL goal to extend his point streak to 13 games for the Lightning (17-9-1), who have won four of five. Andrei Vasilevskiy made 24 saves.
Zac Dalpe scored, and Sergei Bobrovsky made 34 saves for the Panthers (13-11-4).
"I didn't think we moved the puck, managed the puck or moved our feet particularly well tonight," Florida coach Paul Maurice said. "We were trying to play a game slower than the game demanded itself to be played."
Point gave Tampa Bay a 2-1 lead at 3:03 of the third, scoring short side on Bobrovsky after receiving a pass from Nikita Kucherov in the slot.
Mikhail Sergachev made it 3-1 at 7:22 when he shot into an open net after Bobrovsky was knocked down by Lightning forward Pierre-Edouard Bellemare. Maurice challenged the play for goaltender interference, but the call stood after it was determined that Aaron Ekblad pushed Bellemare into Bobrovsky.
Stamkos extended the lead to 4-1 at 16:45 on a breakaway. He has 20 points (eight goals, 12 assists) during his point streak.
"We've had that for the past few years, where if we're in a hockey game, whether it's tied or up one or down one, that we realistically believe that we can win," Stamkos said. "In the third period, we knew if we could stay 5-on-5, I liked our game. [Vasilevskiy] made the big saves when he had to, and we capitalized on our chances."