Auston Matthews and Zach Aston-Reese scored, and Ilya Samsonov made 26 saves for the Maple Leafs (44-20-10), who lead the Tampa Bay Lightning by six points, with one game in hand, for second in the Atlantic Division.
"Other than the first five minutes or so, I thought we played a pretty good game, but obviously you leave the rink a little bit sour just not getting that extra point there at the end," Matthews said. "I think there's plenty of things you can take away from the game, but obviously still not ideal."
Florida was without goalie Sergei Bobrovsky, who started 16 of the previous 17 games, due to a non-COVID illness. Coach Paul Maurice said Bobrovsky was sent earlier Wednesday to Montreal, where the Panthers will face the Canadiens on Thursday. He will be reevaluated prior to the game.
Lyon kept it tied 2-2 when he outwaited Matthews, who cut to the net at 1:18 of overtime, then made a glove save on Matthews at 1:21 after he came out from behind the net.
"I don't know what happened on the one I took across, I kind of mishandled it at the last second, and then he made a nice save on the second try," Matthews said. "But I'll take those any chance I can get, and in my mind, those are going in more times than not."
Lyon said he reviewed footage from the Panthers' 6-2 loss to the Maple Leafs on March 23 with Bobrovsky prior to the game, which he said helped him anticipate what Matthews might do on the second chance.
"'Bob' and I looked at that, he scored on 'Bob' like that in Florida last week, and so we talked about that a lot, how he's so good at moving to the net front quickly, coming high and then going low glove," Lyon said. "To me, it's one of his signature moves, so I just tried to anticipate it and obviously it worked out."