Andersen was scratched from a 5-4 overtime win against the Anaheim Ducks on Friday after being injured Monday.
"It's a disruption, but we're in a place where we think a disruption is healthy," Toronto coach Sheldon Keefe told TSN before the game Friday. "That's what we talked about this morning. We're moving on from what we've been through here the last couple games, giving up points. It's a chance for new blood, new energy in the room and a new opportunity for us to have a good weekend."
Jack Campbell, who was acquired in a trade with forward Kyle Clifford from the Los Angeles Kings on Wednesday, made 26 saves to win his Maple Leafs debut Friday and will start again Saturday.
"I was a little nervous [in] the first period," Campbell said. "But I was just really excited, and I think when you care a lot you get a little nervous, so I got it out in the first. The boys played really well in front of me. Anytime you score five that should be a win -- anytime. I'll clean up my game, but just really excited that the team got two points and moving on to a big game tomorrow."
Campbell hadn't played since Jan. 30. Michael Hutchinson, who was the backup Friday, is 4-9-1 with a 3.66 goals-against average and .886 save percentage this season.
"He's the hardest-working guy I've ever seen in hockey," Muzzin told TSN of Campbell. "I've trained with him in the summer the last two years down in L.A., and just his preparation, coming to the rink and throughout the summers and throughout practice, battling on every puck, extra work, early on the ice, all that kind of stuff."
Andersen was injured during the first period of a 5-3 loss to the Panthers on Monday. He did not accompany the Maple Leafs for the 5-3 loss at the Rangers on Wednesday but skated Friday morning.
Andersen, who played in the NHL All-Star Game for the first time this season, is 24-9-6 with a 2.87 GAA and .910 save percentage. The Maple Leafs (29-19-7), who are 5-10-1 without Andersen in goal, are one point ahead of the Panthers for third place in the Atlantic Division.