"It's a big concern," coach Rod Brind'Amour said after practice Wednesday. "Goaltending is the most important part of the deal, so we're definitely concerned."
Andersen sustained the injury during the third period of a 7-4 loss to the Colorado Avalanche on Saturday while extending his left leg to make a save.
"Give me a week and we can reassess," Brind'Amour said. "We've got to give it time to see where it's at."
Andersen is tied for sixth among NHL goalies in wins (35-14-3), is second in goals-against average (2.17) behind Igor Shesterkin of the New York Rangers (2.05) and is tied for sixth in save percentage (.922) among goalie to play at least 10 games. He also has four shutouts.
Antti Raanta made 23 saves for the Hurricanes in a 5-3 win against the Arizona Coyotes on Monday. Pyotr Kochetkov was recalled from Chicago of the American Hockey League on an emergency basis Sunday and was the backup goalie. He has yet to make his NHL debut.
Raanta is 13-5-4 with a 2.46 GAA, .912 save percentage and two shutouts in 25 games (23 starts).
The Hurricanes (49-20-8) are tied with the Rangers for first in the Metropolitan Division.
"We're still playing for something," Brind'Amour said. "I think we're going to go day to day on how we approach [the goaltending]. You don't want to get rusty and you want to stay in rhythm."
Jordan Staal, who did not play against the Coyotes because of an upper-body injury, is expected to return when the Hurricanes host the Winnipeg Jets on Thursday (7 p.m. ET; BSSO, TSN3, ESPN+, NHL LIVE)). The forward was injured after scoring two goals against Colorado on Saturday.
Jesperi Kotkaniemi, a forward who played two games after missing eight with a lower-body injury, will miss his second straight game.
"I don't think it's anything serious, but it's related to the injury he had before," Brind'Amour said. "He's not 100 percent. No reason to put (him) in."
NHL.com independent correspondent Alan Robinson contributed to this report