The center, selected by the Devils with the No. 1 pick in the 2019 NHL Draft, isn't making the trip to Buffalo and will miss his second straight game after sustaining a lower-body injury blocking a shot during New Jersey's 6-4 win at the Montreal Canadiens on Thursday. He did not practice Friday and didn't dress for a 4-0 home loss to the New York Rangers on Saturday.
The Devils said he's day to day but might be able to play Tuesday against the Vegas Golden Knights at Prudential Center.
Hughes has 11 points (four goals, seven assists) in 24 games but has two assists in his past 10.