Also, forward Paul Byron is presumed to be out one month after having knee surgery Tuesday.
Drouin was placed on injured reserve Saturday. The Canadiens said the injury occured during the third period of a 5-2 win against the Washington Capitals at Capital One Arena on Friday. The 24-year-old forward had left the game after a hit by Capitals forward Alex Ovechkin at 4:14 of the second period. Montreal coach Claude Julien said Drouin went through concussion protocol before returning for the start of the third.
Drouin has 15 points (seven goals, eight assists) in 19 games.
Byron, who also was injured during the third period Friday, did not play in a 4-3 overtime loss to the New Jersey Devils on Saturday. The 30-year-old has four points (one goal, three assists) in 19 games.
The Canadiens (11-5-4) play the Columbus Blue Jackets at Nationwide Arena on Tuesday (7 p.m. ET; FS-O, TSN2, RDS, NHL.TV).