Huberdeau was injured with about 6:45 remaining in the first period against the New Jersey Devils when his left ankle was cut by a skate. Huberdeau was behind the net and engaged with Devils forward Sergey Kalinin when Kalinin's right leg came up and then down on the back of Huberdeau's left ankle.
Huberdeau, 23, signed a six-year contract extension worth $5.9 million annually on Sept. 7 that begins next season. He had 20 goals and 39 assists (59 points) in 76 games last season.
"We're hoping for the best with Jonathan. You just don't replace a player like that," coach Gerard Gallant told the Miami Herald.
The Panthers this week said forward Nick Bjugstad is out at least four weeks with a broken hand.
Florida defeated New Jersey 4-2 in the game at the U.S. Military Academy in West Point, N.Y.
