Scheifele, 24, the No. 7 pick of the 2011 NHL Draft, said he didn't detect much special attention from the Blues in his return.
"I don't know. I took a few later hits, so maybe, but anyone coming back from injury, they're going to be hard on you," he said. "They're going to make sure they finish their check, and that's just part of the game."
Scheifele started on a line with Blake Wheeler, who played center for the Jets in his absence, and Patrik Laine.
When Winnipeg fell behind in the second period, coach Paul Maurice switched Mathieu Perreault into Laine's place.
"I thought [he] played hard," Wheeler said. "It's tough to come back under those circumstances against a tough opponent at this time of year. I thought he was driving and gave us a great effort tonight."
Maurice was asked if he thought the Jets relaxed too much or let their intensity fall simply because their No. 1 center returned from injury.
"I didn't feel that," Maurice said. "I thought [Scheifele] looked like everybody else. It would be hard to separate his game. He got better, skated better, as the game wore on. He got into the groove a little bit. He's been out a long time."
While Scheifele was out the Jets went 11-2-3. They are tied with the Nashville Predators for first place in the Central Division with 73 points.
"I think through the whole year we've lost some key players, guys that do certain things well for us," defenseman Dustin Byfuglien said. "So losing Mark was obviously going to be one of those things and we didn't know how we'd handle it.
"But Blake going to the middle and other guys getting more ice time, everyone has stepped up and played their role very well and our game didn't change. We just stuck to our game plan and we did the right things."
Byfuglien said the confidence the Jets built with a sharp first half before Scheifele was injured simply carried on.
"Around the room, there was never panic," he said. "It was 'Scheif is out so the next guy needs to step up.' And whoever stepped up pulled the same rope the same way."
Scheifele and the Jets face their next test Sunday when the New York Rangers visit Bell MTS Place (3 p.m. ET; NHLN, TSN3, MSG+, NHL.TV).