Crosby batted a puck down and turned up ice, sending a cross-ice pass to Hagelin, who quickly returned it to Crosby who tapped a pass to Dumoulin drifting toward the left post. Dumoulin took a wrist shot to put Pittsburgh ahead 4-0.
Alex Stalock replaced Dubnyk, who made 17 saves on 21 shots, following Dumoulin's goal. Stalock stopped 16 of 18 shots.
"[Pittsburgh's] a good hockey team. They have a lot of speed and a lot of firepower," Dubnyk said. "So, sometimes they're going to be able to play well. They're going to be able to force you and pressure and make plays. You can't keep giving it back to them. You can't keep giving the puck back to them.
"They're going to make you pay for it. At some point, you have to try to get your game together and we shot ourselves in the foot over and over."
Malkin scored another power-play goal, which deflected off Suter's skate, to make it 5-0 at 1:42 of the third.
Simon pushed it to 6-0 with his second goal at 2:32.
Wild coach Bruce Boudreau called a timeout following Simon's goal and told his players he wanted them to show pride in the remaining 17:28. Minnesota responded with three straight goals.
"We may not win the game, but you've got to get back to the way you're supposed to play; the basics," Boudreau said.
Eric Staal scored at 8:44 when he got to the loose puck off Nate Prosser's blocked shot and beat DeSmith glove side to make it 6-1.