Hoffman was a healthy scratch the previous two games and three of the previous six.
"It's the NHL," the forward said. "It's part of the business that we work in. Those are the things that happen throughout a season. Sometimes, you've got to deal with them."
Vince Dunn had three assists, and Husso made 28 saves for the Blues (19-16-6), who have won three in a row after a seven-game slide (0-6-1).
Nico Sturm and Dumba scored, and Talbot made 27 saves for the Wild (24-13-3), who have lost three of four, including 9-1 here Friday.
"The response was great, absolutely great," Minnesota coach Dean Evason said. "We competed our butts off. One-hundred percent, it was businesslike. We rolled the lines. Every line did the right things. We got a couple of bad bounces this game. I don't want to say we deserved better because both teams played really well. It was right there. We caught a couple bad bounces, and that was the difference in the hockey game."
The teams will finish a three-game series at Minnesota on Monday.
Dumba gave the Wild a 2-1 lead at 18:12 of the second period when he scored a power-play goal with a one-timer from the left face-off circle off a pass from Ryan Suter.