Schmidt (lower body), a defenseman, played 3:11 in the season opener against the San Jose Sharks on Oct. 2 before colliding knees with Sharks forward Logan Couture. Tuch (upper body), a forward, has not played since sustaining an injury in a preseason game against the Los Angeles Kings on Sept. 27.
The Golden Knights have won six of their past nine games (6-3-0) after going 2-2-0 in their first four games.
Montreal, winners of four of its past six games (4-2-0), is playing the second game of a back-to-back set after a 4-1 win against the Arizona Coyotes on Wednesday. Goalie Keith Kinkaid is expected to start.