Dylan Larkin gave Detroit a 1-0 lead at 4:09 of the second period with a wrist shot from the left face-off dot. It was Larkin's team-leading 23rd point (nine goals, 14 assists) in 19 games.
"He's our No. 1 center, so he's going to be playing in every situation," Red Wings coach Derek Lalonde said. "He's limiting his turnovers and he's limiting his mistakes in the [defensive] zone. That's what you need from your top player. He's committed to do things correctly and he's getting rewarded."
Nashville had a 5-on-3 man-advantage for 1:36 shortly after Larkin's goal, but Husso made several key stops to keep the Red Wings in front. He made 12 saves in the second.
"When you are down two guys, you need your goalie to be the best player on the ice and [Husso] was," said Larkin, the Red Wings captain. "He made some big saves, and the crowd was going crazy. I thought that gave us a lot of energy."
Predators captain Roman Josi thought Husso's performance on the 5-on-3 changed the game.
"Towards the end, we had a couple of good looks and a couple of good one-timers, and he made some big saves," Josi said. "If you get almost two minutes at 5-on-3, you've got to find a way to score."