Bryan Rust and Jeff Carter each scored for the first time this postseason for the Penguins, the No. 1 seed in the MassMutual East Division. They had lost 10 of their previous 11 playoff games dating to 2018.
Semyon Varlamov made 43 saves for the Islanders, the No. 4 seed, after missing Game 1 for an undisclosed reason. Rookie Ilya Sorokin made 39 saves on 42 shots for New York in the series opener.
"I thought [Varlamov] was excellent after the first goal," Islanders coach Barry Trotz said. "I thought there were moments where they could've made it a 3-1 game and he came up with some key saves. … I thought he was moving well. He was crisp. All of that."
Game 3 will be at Nassau Coliseum on Thursday (7 p.m. ET; NBCSN, SN360, MSG, MSG+, ATTSN-PT).
Rust put the Penguins ahead 1-0 at 3:22 of the first period, scoring on a wrist shot glove side from above the right face-off circle.
"I think, for us, we're just trying to get out there and get to our game as fast as we can," Rust said. "Get out there, have a good start, create some momentum. Obviously, when you score the first goal, there's no better way of doing that."
Carter made it 2-0 at 13:07 when he scored his first playoff goal since April 22, 2016, for the Los Angeles Kings. After taking a pass from Jared McCann, Carter skated by New York defenseman Ryan Pulock to the slot for a wrist shot.
The Penguins outshot the Islanders 19-13 in the first period after having an 18-13 shot advantage in the first in Game 1.
"There's no magic pill that I can give everybody, 'Take this and have a good start,'" Trotz said. "It comes from within. … It's on the room to do that. They know. We've talked about that, getting off to a good start. Best way you can is simplify your game, get after it, get determined, win your battles. Usually, it works out that way."