Michael Bunting had two assists for Toronto (50-20-6), which moved six points ahead of the Tampa Bay Lightning for second place in the Atlantic Division and set its single-season records for wins and points (106). Jack Campbell made 27 saves.
The Maple Leafs won 49 games and had 105 points in 2017-18.
"We've put in a lot of work this season, over the summer, and it's nice to see some results, but in the end that's not the big result that we want," Nylander said.
Toronto played without forward Auston Matthews, who is
day to day because of a "minor injury,"
according to coach Sheldon Keefe. Matthews leads the NHL with 58 goals and has 102 points. The Maple Leafs are 5-1-0 without him this season.
"It's hard to replace an Auston, I don't know if you can," Campbell said. "No disrespect to anybody else, but he does so many world-class things. He just means so much to our dressing room, on the ice and off the ice. But man, what a great opportunity it was for everybody to step up without him tonight, and I thought everybody battled super hard and got a big win."