Chris Kreider scored twice, Adam Fox and Vincent Trocheck each had a goal and an assist, and Alexis Lafreniere and Mika Zibanejad each had two assists for the Rangers (2-0-0), who visit the Winnipeg Jets on Friday. Igor Shesterkin made 33 saves.
"That's what we see with our lineup," New York coach Gerard Gallant said. "There's a lot of skill and talent there, and as long as we work hard, we'll get scoring from all over the place.
Matt Boldy scored twice for the Wild, who were playing their season opener. Marc-Andre Fleury made 28 saves.
"I'd give [the two goals] back in a heartbeat," Boldy said. "We just got blown out of the rink. It's nothing you look on too much."
Kreider gave New York a 1-0 lead at 4:06 of the first period with a power-play goal. Panarin passed to Zibanejad, who faked a one-timer in the left circle and sent a backdoor pass to Kreider at the right post.