Erik Karlsson and Jake Middleton are not playing against the Buffalo Sabres.
The defensemen each sustained an upper-body injury in a 6-2 loss to the Detroit Red Wings on Tuesday.
"They're both possibilities for Saturday (against the Philadelphia Flyers), but I wouldn't be surprised maybe until next Tuesday at home (against the Detroit Red Wings)," Sharks coach Bob Boughner said. "We're still sorting that out. Taking it day by day."
Karlsson has scored 22 points (eight goals, 14 assists) in 28 games. Middleton has eight points (three goals, five assists) in 28 games.
The Sharks also are playing without goalie James Reimer, who has a lower-body injury.
"He's dealing with some maintenance things really with his body and his game, and we want to make sure we give him the proper time to feel better before he gets back into action," Boughner said. "It's unfortunate because 'Reims' had such a great start to the season and like the rest of our team, it's dipped a little bit. I know he'll get back there but we want to make sure when he does, he's close to 100 percent to give him that chance for success."
Reimer is 11-7-1 with a 2.68 goals-against average and .916 save percentage in 20 games (19 starts) this season. -- Heather Engel