Arizona Coyotes at Pittsburgh Penguins (7 p.m. ET; ATTSN-PT, BSAZ, ESPN+, SN NOW)
Sidney Crosby, Evgeni Malkin and Kris Letang begin their 17th season as Penguins teammates, extending the NHL record for the longest run with one team by three players. The Coyotes open with a six-game road trip before playing their first game at Mullett Arena in Tempe, Arizona, on Oct. 28.
New Jersey Devils at Philadelphia Flyers (7 p.m. ET; ESPN+, HULU, SN NOW)
John Tortorella begins his tenure as Flyers coach against the rival Devils. New Jersey also has a different look after adding some experience to its young core by signing two-time Stanley Cup winning forward Ondrej Palat and defenseman Brendan Smith, and trading for forward Erik Haula (from the Boston Bruins), defenseman John Marino (Penguins) and goalie Vitek Vanecek (Washington Capitals).
Ottawa Senators at Buffalo Sabres (7 p.m. ET; MSG-B, TSN5, RDS, ESPN+, SN NOW)
Forwards Claude Giroux, who signed a three-year contract, and Alex DeBrincat, acquired in a trade with the Chicago Blackhawks, will debut for the Senators, who have their sights set on qualifying for the playoffs for the first time since 2017. After playing his first eight NHL games at the end of last season, 19-year-old defenseman Owen Power, the No. 1 pick in the 2021 NHL Draft, begins his first full season with the Sabres.
Florida Panthers at New York Islanders (7:30 p.m. ET; MSGSN, BSFL, ESPN+, SN NOW)
In addition to Tkachuk's Panthers debut, this will be Lane Lambert's first game as coach of the Islanders after he replaced Barry Trotz. New York opens this season at home after playing its first 13 games on the road last season while construction of UBS Arena was completed.
Washington Capitals at Toronto Maple Leafs (7:30 p.m. ET; TVAS, TSN4, NBCSWA, ESPN+, SN NOW)
Goalie Ilya Samsonov's debut for Toronto, which signed him to a one-year contract July 13, coincidentally comes against Washington, which decided not to make him a qualifying offer as a restricted free agent after last season. The Maple Leafs play their home opener after starting their season with a 4-3 loss at Montreal Canadiens on Wednesday. The Capitals also lost their opener, 5-2 at home to the Bruins on Wednesday.
New York Rangers at Minnesota Wild (8 p.m. ET; BSN, BSWI, MSG, ESPN+, SN NOW)
Wild goalie Marc-Andre Fleury begins his 19th season needing 32 wins to pass Patrick Roy (551) for second in NHL history. The Rangers look to build on their 3-1 home win against the Lightning in their season opener Tuesday.
Dallas Stars at Nashville Predators (8:30 p.m. ET; ESPN+, HULU, SN NOW)
The Stars play their first game under coach Peter DeBoer, who replaced Rick Bowness (now coach of the Winnipeg Jets). The Predators play their home opener after winning back-to-back games against the Sharks at the NHL Global Series. Nashville's David Poile is one win from becoming the fifth general manager to reach 900 with one team and nine from being the first in NHL history to reach 1,500.
Colorado Avalanche at Calgary Flames (9:30 p.m. ET; SN1, ALT, ESPN+, SN NOW)
The Avalanche have a quick turnaround after raising their Stanley Cup banner and opening with a 5-2 win against the Blackhawks on Wednesday. The Flames will look to win their season opener for the first time since 2009-10 (0-10-2).
Chicago Blackhawks at Vegas Golden Knights (10 p.m. ET; ATTSN-RM, NBCSCH, ESPN+, SN NOW)
The Golden Knights play their home opener after beginning with a 4-3 victory at the Los Angeles Kings on Tuesday. The Blackhawks continue a season-opening three-game road trip.
Seattle Kraken at Los Angeles Kings (10:30 p.m. ET; BSW, ROOT-NW, ESPN+, SN NOW)
The Kraken (5-4 overtime loss at the Anaheim Ducks on Wednesday) and Kings will each try to rebound from a season-openining loss. Los Angeles defenseman Drew Doughty, forward Anze Kopitar and goalie Jonathan Quick started their 15th season playing together.