Holtby got his blocker on Alex Formenton's penalty shot at 15:51 of the second period.
"A guy I didn't know much about, so I just tried to react," Holtby said.
Holtby has won three starts since the Canucks returned to play last Sunday.
"It's great to see. He's a great person, a great teammate, he's had a great career so far," Vancouver coach Travis Green said. "I'm not a goalie expert by any means, but he definitely looks confident, he looks freer, things look easier for him."
The Senators were 0-for-6 to end a streak of six straight games with a power-play goal, including two in a 3-0 win against the Canucks on Thursday.
"Too fancy," Smith said. "Tried too many slow plays. Sometimes you've just got to fire pucks and bang them in and get numbers at the net."
NOTES: Senators forward Artem Anisimov, who was on their taxi squad, dressed in goalie gear and would have played had Hogberg been injured, according to Smith. … Ottawa forward Nicholas Paul had one shot in 12:34 after missing most of the third period Thursday and practice Friday … Canucks defenseman Alexander Edler had four shots and was plus-2 in 22:33 in his first game back from a two-game suspension for kneeing Toronto Maple Leafs forward Zach Hyman last Sunday. … Canucks forward Tyler Motte had an assist and was plus-1 in 17:05 in his first game back from COVID-19 protocol. He was their last player to return.