The 26-year-old goalie, who has made 15 of his 23 NHL starts this season, also earned his first win since March 25.
"It feels really good," Comrie said. "It's a happy moment for myself. A lot of hard work went into that, but a lot of hard work from the guys tonight. They played a fantastic game and made it real easy for myself to see the puck and make a lot of easy saves because they were playing as good as they could."
Kyle Connor had a goal and two assists, and Blake Wheeler and Nikolaj Ehlers each had a goal and an assist for the Jets (37-32-11).
"[Comrie] is the type of teammate you cheer for every single day," Connor said. "You see it in practices, I'm sure you guys watch it all of the time, he's always one of the last ones off, putting in all of the work. So it's pretty cool to see it pay off."
Felix Sandstrom, who was making consecutive starts for the first time this season, made 23 saves for the Flyers (25-45-11), who will conclude their season against the Ottawa Senators on Friday.
"I think that [Sandstrom is] a battler," Philadelphia coach Mike Yeo said. "He is a competitor, you can tell, and he doesn't get rattled. Giving up a couple goals now in the last couple games and seems to find a way to keep competing and give us a chance to climb back into it."