Crosby had a goal and three assists for the Penguins (30-30-10), who have lost three straight and four of five (1-3-1). Alex Nedeljkovic made 21 saves.
“That's one of the most explosive offenses in the League that we played against,” Pittsburgh coach Mike Sullivan said. “We knew they were going to push back. We competed hard all night.”
Tristan Jarry replaced Nedeljkovic for 10:05 in the third period after a collision with Casey Mittelstadt. Jarry allowed one goal on five shots.
“We played good enough to win that game. I mean, they're a really good hockey team,” Nedeljkovic said. “To hold them to four shots in the first period, to be up 4-0 with four to play in the second period and not come away with two points, it's pretty disappointing.”
Sean Walker started the Avalanche comeback when he made it 4-1 at 16:05 of the second period with a wrist shot from above the right circle through a screen.
The goal came 25 seconds after Pierre-Olivier Joseph extended the lead to 4-0.
Yakov Trenin made it 4-2 at 19:30 of the second with a deflection of Brandon Duhaime’s shot.
“I think 'Pitt' played really well tonight,” Bednar said. ‘They gave us more than we could handle through at least 30 minutes of that game, and I think it took an exceptional effort from our guys tonight to win that hockey game. It took our whole roster, our depth, like everybody involved in it.”
Drouin cut the lead to 4-3 at 3:32 of the third period, scoring with a one-timer from the right face-off dot off a cross-ice pass from MacKinnon.
MacKinnon then tied the game 4-4 at 15:22 of the third, scoring short side with a one-timer from the left face-off dot off a cross-ice pass from Drouin.