DeBrincat gave the Red Wings a 1-0 lead at 3:46 of the first period, scoring with a one-timer from the left circle off a cross-ice pass from Lucas Raymond.
The Red Wings outshot the Penguins 13-7 in the first period.
“It might help a little bit to be busy early, it gets you a feel for the puck,” Blomqvist said. “They were pressuring hard and I had to battle through it.”
Beauvillier tied it 1-1 at 15:02 of the first . He flipped the puck into the crease from below the goal line and it went in off Red Wings defenseman Ben Chiarot.
Beauvillier then gave the Penguins a 2-1 lead at 2:55 of the second period, putting in a centering pass from Pettersson in front.
Drew O'Connor made it 3-1 at 3:53 with a tap-in at the top of the crease off a feed from Malkin, who deked around multiple Detroit skaters as he carried the puck through the offensive zone.
Pettersson pushed it to 4-1 at 5:28 with a wrist shot from the left point, chasing Husso.
“We got away from that first period game we had, and pucks started going in,” Red Wings captain Dylan Larkin said. “It felt like we were doing things right, but we had too many big-time breakdowns.”