It will be the 30-year-old goalie's first start in the Stanley Cup Playoffs.
"He has a little swagger to him," Penguins coach Mike Sullivan said. "I think that serves him well. It's such an important aspect, I think, of being not only an athlete, but in particular a goalie. I think you can see it in his body language. I think it's contagious with our group. He's an NHL goaltender. He's a very capable guy but he has a confidence about him that I think serves him really wll."
Domingue made 17 saves after replacing Casey DeSmith during the second overtime of the Penguins' 4-3 triple-overtime win in Game 1 on Tuesday. DeSmith made 48 saves before leaving the game 9:18 into double overtime.
DeSmith is day to day and being evaluated for a lower-body injury.
Forward Rickard Rakell also will not play Thursday. The forward is day to day with undisclosed injury after he left Game 1 following a hit by Rangers defenseman Ryan Lindgren at 18:41 of the first period. A major penalty assessed to Lindgren was changed to a minor for roughing following a video review.
Forward Jason Zucker will be a game-time decision. He's been out since sustaining a lower-body injury on April 26.
He would likely skate on the second line to the left of center Evgeni Malkin with Kasperi Kapanen moving up from the third line to replace Rakell.
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Tristan Jarry, Pittsburgh's No. 1 goalie for most of the season, last played April 14 because of a lower-body injury. Coach Mike Sullivan said Jarry continued is rehabiing off the ice, but has yet to start skaing.
Domingue and emergency backup goalie Reid Robertson were on the ice for practice. Alex D'Orio was recalled from Wilkes-Barre/Scranton of the American Hockey League and is expected to back up Domingue in Game 2.
Domingue's previous NHL postseason game came with the Tampa Bay Lightning, in relief of Andrei Vasilevskiy in Game 1 of the 2018 Eastern Conference Final. Domingue made seven saves in 18:25 of ice time in a 4-2 loss to the Washington Capitals.
"Louis understands that it's a hockey game, it's the same game he plays all the time," Sullivan said. "That's the approach that we take with all of our players.
"We talk a lot with our guys about just staying in the moment and just focusing on the task at hand. It's that shift, it's that moment and not getting ahead of yourself, but not getting overwhelmed by the circumstances or the noise that goes around playoff hockey. We're going to control what we can. We're going to stay in the moment and that's the approach that we're going to take. It's a short-sighted focus that's essential to have success at this time of year"
Domingue was the Penguins' No. 3 goalie for most of the season. He played two regular-season games with Pittsburgh and was 10-9-2 with a 2.41 GAA and .924 save percentage in in 22 AHL games.
The Penguins are Domingue's sixth NHL team. In eight seasons with the Penguins, Lightning, Calgary Flames, Vancouver Canucks, New Jersey Devils and Arizona Coyotes he is 59-60-10 with a 3.04 GAA, .905 save percentage and two shutouts in 142 games (126 starts).
"He's a goalie that's shown an ability to have success at this level," Sullivan said. "He's an NHL goalie. He's played a significant amount of games at this level and he's shown an ability to have success. I think that's what our management and hockey ops recognize."
