Karlsson made it 2-0 at 7:37 when he scored through traffic from the right point.
"I think giving one up early on the power play allowed their skill guys to get feeling it a little bit," Flyers defenseman Travis Sanheim said. "You could just sense it, they were making plays."
Tippett cut it to 2-1 at 14:55 on the power play with a wrist shot from the right circle. It was his first goal in seven games.
Ruhwedel pushed it to 3-1 at 8:07 of the second period, scoring his first goal of the season on a wrist shot from the high slot.
"Third goal was the one that gets you," Tortorella said. "We spent too much time in our end zone. We didn't come out clean enough. ... We just weren't clean coming out and if you give that team opportunities on breakouts, sooner or later the momentum changes. I thought we fought, we just struggled scoring. We don't have enough people going offensively. They were the better team."
Malkin put a snap shot from the right circle over Hart’s blocker at 4:29 of the third period for the 4-1 final.
"I think he's playing hard, he's competing hard," Penguins coach Mike Sullivan said of Malkin. "I think he's just doing a better job at some of the subtleties or the little small details in his game, like stopping on pucks and not playing as much in constant motion. 'Geno' is a guy that likes to play in motion, but there are some times when you have to stop on pucks, and I think he's doing a much better job just paying attention to those types of situations."
NOTES: The Flyers traded forward Cutter Gauthier, the No. 5 pick of the 2022 NHL Draft, to the Anaheim Ducks for defenseman Jamie Drysdale and a second-round pick in the 2025 NHL Draft. Tortorella said he expects Drysdale to practice Tuesday. ... Rakell's goal was the Penguins’ fastest to open a game this season. ... Pittsburgh has scored a power-play goal in four straight games, its longest streak since scoring at least one in each of the final four games of last season. ... Karlsson's goal extended his point streak to four games (one goal, four assists). ... Ruhwedel’s goal was his first since March 25, 2023. ... Penguins defenseman Kris Letang had his streak of three straight road games with at least three points end. He had been one of six NHL defensemen to accomplish the feat. ... Flyers forward Travis Konecny had his seven-game point streak end (five goals, five assists).