"He's done for the year, so that's unfortunate, obviously," Maple Leafs coach Mike Babcock said. "Lower-body injury there. It's one of those things. [Brooks] Orpik is a good man, he plays hard, he didn't mean to hurt anybody; it's just one of those things and it's unfortunate for Polak."
Polak was injured falling awkwardly after a collision with Orpik along the boards with 6:05 left in the second period. He could not put weight on his leg and was helped off the ice by teammates.
The Maple Leafs played into two overtimes with five defensemen. Jake Gardiner (40:34), Morgan Rielly (39:56) and Matt Hunwick (35:46) played more than 35 minutes.
Toronto defenseman Nikita Zaitsev has not played in the series because of an upper-body injury sustained in the last game of the regular season. Polak also left that game briefly but was able to return.
The best-of-7 series is tied 1-1 with Game 3 at Toronto on Monday (7 p.m. ET; NBCSN, CBC, TVA Sports 2, CSN-DC). Toronto won Game 2 on a double-overtime goal by Kasperi Kapanen after Washington won Game 1 3-2 on Thursday on an overtime goal by Tom Wilson.