Draisaitl made it 2-1 at 7:39 of the second off a turnover created by Zack Kassian in the offensive zone.
Brassard made it 3-1 at 6:49 of the third period after his centering pass went in off Karlsson's skate. The forward was making his Oilers debut after being acquired from the Philadelphia Flyers on Monday.
"Acquiring some people at the deadline makes us a deeper team, and I think when you're making a playoff push, having people that can come into the lineup and play important minutes for our group is beneficial going into the most important games of the year," Smith said. "Something that every team looks for is depth, and we acquired some guys that have been in the playoffs before and play important roles on teams, and obviously getting some guys back healthy just solidifies our lineup."
Hertl made it 3-2 at 7:18 when he scored from the slot, but Draisaitl pushed it to 4-2 at 13:55 by redirecting a pass from McDavid on the power play.
Evander Kane scored an empty-net goal at 17:18 for the 5-2 final.
NOTES: Sharks forward Logan Couture left the game in the second period after being hit with a shot. "Just upper-body. I think he wasn't fit to come back," Boughner said. "He'll be assessed tomorrow. Hopefully, it's just a day-to-day thing. Just got that shot up high." ... Oilers forward Ryan Nugent-Hopkins had a game-high seven shots on goal in 17:32 of ice time after missing 12 games with an upper-body injury. … Defenseman Brett Kulak had one shot on goal and two hits in 18:27 of ice time in his Oilers debut after being acquired from the Montreal Canadiens on Monday. … Draisaitl extended his point streak to seven games (six goals, five assists) and has scored 90 points (44 goals, 46 assists) in 65 games this season. … McDavid extended his point streak to eight games (six goals, 10 assists) and has scored an NHL-leading 95 points (35 goals, 60 assists) in 64 games this season. … Yamamoto has scored 12 points (seven goals, five assists) in his past eight games. … Hertl has scored 10 points (four goals, six assists) in his past eight games.