The forward was injured in Game 5 on Sunday.
Defenseman Erik Karlsson and forward Tomas Hertl also are not playing after being injured in that 5-0 loss that put San Jose on the brink of elimination. Karlsson and Hertl did not travel to St. Louis.
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Forward Timo Meier, who did not take part in the morning skate, is in the Sharks lineup, along with forwards Dylan Gambrell and Marcus Sorensen, and defenseman Tim Heed.
"We've relied on our depth all year," Sharks coach Peter DeBoer said. "This isn't new to our group. We have depth and we have guys that can come in and get the job done."
Pavelski, the Sharks captain, had nine points (four goals, five assists) in 13 games. He was injured 1:21 into the third period of Game 5 on a hit from Blues defenseman Alex Pietrangelo.
Pavelski did not play the first six games of the second round against the Colorado Avalanche after he was injured in Game 7 of the first round against the Vegas Golden Knights.
Gambrell played one postseason game, April 26 in the second round against the Avalanche. Sorensen was scratched for two of the past three games; he had five assists in 17 postseason games.
Game 7 would be Thursday at San Jose.
