Steven Lorentz gave San Jose a 1-0 lead at 14:13 of the first period, knocking in a loose puck at the side of the net.
Niederreiter tied it 1-1 at 6:05 of the second period when he spun and fired a wrist shot from the edge of the left face-off circle.
It was Niederreiter's first goal since being acquired in a trade from the Nashville Predators on Feb. 25, and the 200th of his NHL career.
"It definitely felt great, but right now, obviously, we lost, so that's above everything else," Niederreiter said. "It's not very important right now. It's great to get on the board, but it's tough that we lost.
"[I] hope I'm not going to stop here; I'm trying to get more and more. [Two hundred is] definitely a great mark and I'm definitely proud of it, but hopefully there's more to come."