Owen Pickering put Pittsburgh ahead 1-0 at 9:20 of the first period with his first NHL goal, a wrist shot from the point past a screen from Michael Bunting. The 20-year-old was selected in the first round (No. 21) of the 2022 NHL Draft.
Malkin made it 2-0 at 10:32 on a wrist shot from the slot off a no-look backhand pass from Philip Tomasino.
The goals came just after Jesper Boqvist appeared to give the Panthers a lead at 8:26 but it was overturned after Anton Lundell was ruled offside on a Penguins challenge.
Tkachuk cut it to 2-1 at 17:24 with a wrist shot to end a six-game goal drought.
Kris Letang extended the lead to 3-1 at 6:54 of the second period with a one-timer through traffic from a sharp angle.
“Obviously, you want those points against a good team like this,” Letang said. “Was it our best game? No, it wasn’t. But you have to give us credit. Even when they tied it, we kept playing and we got a big extra point out there.”
NOTES: Tkachuk had three points (one goal, two assists) in the third period. Only two players in Panthers history have had more in one period: Noel Acciari (four points; three goals, one assist in the second period on Dec. 20, 2019) and Olli Jokinen (four points; two goals, two assists in the third period on March 17, 2007). ... Crosby's assist on Pettersson's goal was his 1,022nd in the NHL, one from tying Gordie Howe (1,023) for the fifth most by a player with a single franchise. ... Goalie Sergei Bobrovsky, expecting the birth of a child, did not travel with the Panthers. ... Knight became the 150th different goalie Malkin has scored against. Washington Capitals forward Alex Ovechkin (178) and Crosby (150) are the only active players to have scored on as many goalies.