Seth Jarvis had a goal and two assists, and Guentzel and Aho each had a goal and an assist for the Hurricanes, who are the No. 2 seed from the Metropolitan Division. Andersen made nine saves.
“It was a special night, for sure,” Carolina coach Rod Brind’Amour said. “It’s one of those games we’ll look back on for a long time. It’s a once-in-a-lifetime type game.”
Kyle Palmieri, Bo Horvat and Anders Lee scored for the Islanders, who are the No. 3 seed from the Metropolitan. Varlamov made 34 saves.
Carolina leads the best-of-7 series 2-0. Game 3 will be in Elmont, New York, on Thursday.
“It’s a tough loss, no doubt about it, because we had a chance to win that game,” New York coach Patrick Roy said. “But at the same time, we’ve got to regroup and be ready for the next game. We’re going home and we need to play well at our building and win game No. 3, that’s all.”
Palmieri gave the Islanders a 1-0 lead at 16:22 of the first period. Andersen stopped Palmieri's initial chance from in close, but the forward found the rebound in the crease and jammed the puck into the open net.
Horvat made it 2-0 at 19:45 with a one-timer blocker side from the high slot off a pass from Mathew Barzal.
Lee pushed the lead to 3-0 with a power-play goal at 3:54 of the second period. After taking a short pass from Jean-Gabriel Pageau at the top of the crease, Lee pulled the puck to his backhand and tucked a shot around Andersen’s left pad.
The Hurricanes controlled play the rest of the way, though, outshooting the Islanders 29-5 over the final two periods, when they spent the majority of the time in the offensive zone. They also held a 110-28 advantage in shot attempts for the game.
“As a group, you support one another defensively, and there’s times we got hemmed in,” New York forward Brock Nelson said. “I thought guys laid it on the line a couple times when were were stuck because of broken sticks, which obviously hurts. You’d like to be playing more in the offensive zone, for sure.”
Teuvo Teravainen cut the lead to 3-1 with a power-play goal at 13:01 of the second. Varlamov stopped Jarvis' shot from the left circle, but the rebound went to Guentzel, who quickly fed Teravainen for a shot into an open net.
“It gives you hope, it gives you a chance,” Brind’Amour said. “We went into the [third] period down two, so it wasn’t a total disaster of a period. Guys felt good about how they were playing.”