Mikko Rantanen had four assists, and Gabriel Landeskog and Cale Makar each had a goal and an assist for Colorado (21-8-2), which set an Avalanche/Quebec Nordiques record with its 11th straight home win. Pavel Francouz allowed one goal on 19 shots after relieving Darcy Kuemper (three goals on eight shots) at 14:50 of the first period.
"We just needed to change something," Avalanche coach Jared Bednar said. "I don't put that on Kuemper at all. I'd love to see him come up with one of those, but he just wasn't finding it. I was just trying to send a message to our group. It just shows what our team is capable of if we work like that at both ends."
Auston Matthews scored two goals, and Alex Kerfoot had a goal and two assists for Toronto (22-8-3), which had won four straight. Campbell made 44 saves.
"I take nothing but positives out of this game tonight," Maple Leafs coach Sheldon Keefe said. "All things considered, this team we were playing tonight, they're rolling. It's a tough building to play in. It's probably the loudest building we played in all year. So you come out of playing in front of no fans (in Toronto) to something like this, the response to start the game I thought was outstanding.
"Would we like to get two points? Absolutely. Should we have had two points? Absolutely, but that's a very good team and to come in here and get a point is huge for this group."
Kerfoot gave the Maple Leafs a 1-0 lead at 7:54 of the first period with a one-timer from between the face-off circles.
Matthews made it 2-0 at 14:17 on a shot from the slot. He scored 33 seconds later to make it 3-0 at 14:50 with a shot from the slot off a pass from behind the net from Kerfoot, prompting Bednar to make the goalie change.
"It's something teams usually do to get the team going," Francouz said. "We started playing well in the second period. To me, it was just a matter of time before we started scoring. I was just trying to enjoy every minute on the ice, especially in a game like this when it's possibly the two most talented teams in the League."