Seider gave the Red Wings a 1-0 lead at 4:45 of the first period. Murray made the initial save on Dominik Kubalik's shot, but he couldn't find the rebound, and Seider finally got the puck over the line during a scramble in the crease.
Matthews tied it 1-1 at 8:24, scoring with a wrist shot from the top of the slot for his 11th goal.
William Nylander made it 2-1 with a power-play goal at 9:15, and Marner extended it to 3-1 with a shot that trickled through Husso's legs 52 seconds into the second period.
Husso was then pulled after he was beat by a shot from Sandin that made it 4-1 at 8:37. Husso was 7-1-2 in his previous 10 games.
"You never want to see your goalie get pulled, but [Husso] would be the first one to say he would wanted a couple of those back," Larkin said. "He said that to us, but we know we've been relying on him a lot lately."
Adam Erne tipped in Seider's shot at 12:41 of the third period to pull Detroit to within 4-2.
NOTES: The Red Wings outshot Toronto 35-20 at 5-on-5, their largest margin of the season, but were outscored 3-2. … Matthews has 29 points (16 goals, 13 assists) in 18 games against the Red Wings, the most he has against any United States-based team. He has 41 points (23 goals, 18 assists) against the Ottawa Senators and 34 points (22 goals, 12 assists) against the Montreal Canadiens, but those are in 27 and 28 games, respectively.